(S,S,S)-AHPC hydrochloride ( (S,S,S)-VH032-NH2 hydrochloride )

Catalog No. M23965 CAS No. 2115897-23-7

(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

(S,S,S)-AHPC hydrochloride
Note

Research use only, not for human use.
Brief Description

(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC.
Description

(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the recruitment of the VHL protein.
Synonyms

(S,S,S)-VH032-NH2 hydrochloride
Pathway

PROTACs
Target

E3 Ligase Ligand
Recptor

VHL
Research Area

——
Indication

——

Chemical Information

CAS Number

2115897-23-7
Formula Weight

467.0
Molecular Formula

C22H31ClN4O3S
Purity

>98% (HPLC)
Solubility

H2O: 99 mg/mL (211.98 mM; Need ultrasonic); DMSO: 60 mg/mL (128.47 mM; Need ultrasonic)
SMILES

O=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@@H](O)C3.[H]Cl
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1.Crew AP, et al. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase J Med Chem. 2018 Jan 25;61(2):583-598.

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