Cart
sales@molnova.com
(S,S,S)-AHPC hydrochloride
CAS No. 2115897-23-7
(S,S,S)-AHPC hydrochloride( (S,S,S)-VH032-NH2 hydrochloride )
Catalog No. M23965 CAS No. 2115897-23-7
(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 32 | In Stock |
|
| 5MG | 53 | In Stock |
|
| 10MG | 77 | In Stock |
|
| 25MG | 125 | In Stock |
|
| 50MG | 178 | In Stock |
|
| 100MG | 295 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product Name(S,S,S)-AHPC hydrochloride
-
NoteResearch use only, not for human use.
-
Brief Description(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC.
-
Description(S,S,S)-AHPC hydrochloride is a VHL amino building block, is a ligand used as a negative control for (S,R,S)-AHPC. It is the VH032-based VHL ligand used in the recruitment of the VHL protein.
-
In VitroThe VHL protein is a substrate recognition subunit of two ubiquitously expressed and biologically important Cullin RING E3 ubiquitin ligase complexes. VHL is one of the most popular E3 ligases being recruited by bifunctional Proteolysis-targeting chimeras (PROTACs) to induce ubiquitination and subsequent proteasomal degradation of a target protein.
-
In Vivo——
-
Synonyms(S,S,S)-VH032-NH2 hydrochloride
-
PathwayPROTACs
-
TargetE3 Ligase Ligand
-
RecptorVHL
-
Research Area——
-
Indication——
Chemical Information
-
CAS Number2115897-23-7
-
Formula Weight467.02
-
Molecular FormulaC22H31ClN4O3S
-
Purity>98% (HPLC)
-
SolubilityH2O: 99 mg/mL (211.98 mM; Need ultrasonic); DMSO: 60 mg/mL (128.47 mM; Need ultrasonic)
-
SMILESO=C(NCC1=CC=C(C2=C(C)N=CS2)C=C1)[C@H]3N(C([C@H](C(C)(C)C)N)=O)C[C@@H](O)C3.[H]Cl
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Crew AP, et al. Identification and Characterization of Von Hippel-Lindau-Recruiting Proteolysis Targeting Chimeras (PROTACs) of TANK-Binding Kinase J Med Chem. 2018 Jan 25;61(2):583-598.
molnova catalog
related products
-
VHL-alkyne
VHL-alkyne is a VHL ligand for PROTAC synthesis.
-
PROTAC-VHL-ligand hy...
PROTAC-VHL-ligand is a von Hippel–Lindau (VHL) ligand used for the proteolysis targeting chimeras (PROTACs) method, induces target protein degradation.
-
VH-032
VH-032 (VHL ligand 1) is a VHL ligand for PROTAC and potent, small molecule inhibitor of the VHL/HIF-1α interaction with Kd of 185 nM.
